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The purity of rh GFRA1 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh GFRA1 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

GFRA 1 Recombinant Protein

CATALOG NUMBER: 96-344

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Asp 25 - Ser 424
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
45.5 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GDNF at 1 μg/mL binds rhGFRA1 with an apparent KD <10 nM.
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
GFRA1
Additional Names:
GFRA1, GDNFRA, RETL1, TRNR1, GDNFR, GFR-ALPHA-1, RET1L
Protein Accession Number:
NP_665736.1
Ncbi Gene Id Number:
2674
Background:
GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.
Background Reference 1:
Angrist M, et al., 1998, Genomics 48 (3): 354–62.
Background Reference 2:
Jing, S., et al., 1997, J. Biol. Chem. (UNITED STATES) 272 (52): 33111–7.
Background Reference 3:
Cik, M., et al., 2000, J. Biol. Chem. (UNITED STATES) 275 (36): 27505–12.
Background Reference 4:
Klein, R D., et al., 1997, Nature (ENGLAND) 387 (6634): 717–21.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-344

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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