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The purity of rh UCHL1 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh UCHL1 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

UCHL1 Recombinant Protein

CATALOG NUMBER: 96-762

Tested Applications:
WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Met 1 - Ala 223
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
25.7 kDa
Purity:
>92% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
20mM Tris, 500mM Nacl,1mM DTT,pH 8.0
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -71°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
UCHL1
Additional Names:
UCHL1, PGP9.5
Protein Accession Number:
NP_004172
Ncbi Gene Id Number:
7345
Background:
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) ,a member of the peptidase C12 family, is also known as neuron cytoplasmic protein 9.5 (PGP 9.5) and ubiquitin thioesterase L1.About 30% of total UCHL1 is associated with membranes in brain. UCHL1 is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also,UCHL1 can bind to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. Furthermore, the mutations of UCHL1 gene can result in parkinson disease 5.
Background Reference 1:
Choi J., et al., 2004, J. Biol. Chem. 279:13256-13264.
Background Reference 2:
Liu Y., et al., 2002, Cell 111:209-218.
Background Reference 3:
Choudhary C., et al., 2009, Science 325:834-840.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-762

List Size:
0.05 mg

List Price:

$463.00

Datasheet
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