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Immobilized Human CD2, His Tag at 2 ug/mL (100 uL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL.
Immobilized Human CD2, His Tag at 2 ug/mL (100 uL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL.

CD58 Recombinant Protein

CATALOG NUMBER: 96-850

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Phe 29 - Arg 215
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
48.1 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human CD2, His Tag at 2 ug/mL (100 uL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL.
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
CD58
Additional Names:
CD58,LFA3,Ag3
Protein Accession Number:
AAH05930
Ncbi Gene Id Number:
965
Background:
CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
Background Reference 1:
Barbosa JA., et al., 1986, J. Immunol. 136 (8): 3085–91.
Background Reference 2:
Wang JH., et al., 1999, Cell 97 (6): 791–803.
Background Reference 3:
De Jager PL., et al., 2009, Proc Natl Acad Sci U S A. 106 (13): 5264–9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-850

List Size:
0.1 mg

List Price:

$495.00

Datasheet
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