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Immobilized Human IGFBP-4, His Tag at 2 ug/mL (100 ul/well),can bind Human IGF-I, Fc Tag with a linear range of 4-30 ng/mL.
Immobilized Human IGFBP-4, His Tag at 2 ug/mL (100 ul/well),can bind Human IGF-I, Fc Tag with a linear range of 4-30 ng/mL.

IGFBP-4 Recombinant Protein

CATALOG NUMBER: 96-890

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Asp 22 - Glu 258
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
27.9 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP-4, His Tag at 2 ug/mL (100 ul/well),can bind Human IGF-I, Fc Tag with a linear range of 4-30 ng/mL.
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
IGFBP-4
Additional Names:
IGFBP4,IBP-4
Protein Accession Number:
AAH16041
Ncbi Gene Id Number:
3487
Background:
Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.
Background Reference 1:
Tagliabracci V.S., et al., 2015, Cell 161:1619-1632.
Background Reference 2:
Culouscou J.M., et al.,1991, Cancer Res. 51:2813-2819.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-890

List Size:
0.05 mg

List Price:

$515.00

Datasheet
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