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Rabbit IL-5, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Rabbit IL-5, His Tag at 5 ug/mL (100 uL/well) can bind Human IL-5 R alpha, Fc Tag with a linear range of 2-78 ng/mL (QC tested).
Rabbit IL-5, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

IL-5 Recombinant Protein

CATALOG NUMBER: 11-122

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Rabbit
source-species:
HEK293 cells
Recombinant Protein Sequence:
Met 20 - Ser 134
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15.2 kDa. The protein migrates as 15 kDa and 16-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
15.2 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
IL5
Additional Names:
IL-5,TRF,IL5,Interleukin-5
Protein Accession Number:
XP_002710247.1
Ncbi Gene Id Number:
100358075
Background:
Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.
Background Reference 1:
Milburn MV, et al. 1993. Nature. 363(6425):172-6.
Background Reference 2:
Shen HH, et al. 2003. J Immunol. 170(6):3296-305.
Background Reference 3:
Sanderson CJ, et al. 1992. Blood. 79 (12): 3101–9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-122

List Size:
0.05 mg

List Price:

$577.00

Datasheet
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