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Human TNFSF11, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Osteoprotegerin, His Tag at 2 ug/mL (100 uL/well) can bind Human TNFSF11, Mouse IgG2a Fc Tag with a linear range of 0.2-2 ng/mL (QC tested).
Immobilized Human TNFSF11, Mouse IgG2a Fc Tag at 2 ug/mL (100 uL/well) can bind Anti-Human TNFSF11 Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (Routinely tested).
Human TNFSF11, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

TNFSF11 / RANKL / CD254 Recombinant Protein

CATALOG NUMBER: 11-157

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gly 64 - Asp 245
Fusion Tag:
Mouse IgG Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 47.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
47.4 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
TNFSF11
Additional Names:
RANKL,CD254,TRANCE,OPGL,ODF
Protein Accession Number:
AAC51762.1
Ncbi Gene Id Number:
8600
Background:
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
Background Reference 1:
Hanada R., et al., 2011, J. Mol. Med. 89 (7): 647-656.
Background Reference 2:
Findlay DM., et al., 2011, Osteoporos Int. 22 (10): 2597-2602.
Background Reference 3:
Schmiedel BJ., et al., 2013, Cancer Res. 73 (2): 683-694.
Background Reference 4:
Castellano D., et al., 2011, Oncologist. 16 (2): 136-145.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-157

List Size:
0.05 mg

List Price:

$577.00

Out of stock

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