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Human GDF-15, His Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human GDF-15, His Tag at 1 ug/mL (100 uL/well) can bind Human GFR alpha-like Fc Chimera Protein with a linear range of 0.2-8 ng/mL (QC tested).
Human GDF-15, His Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

GDF-15 / MIC-1 Recombinant Protein

CATALOG NUMBER: 11-261

Tested Applications:
ELISA, WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Ala 197 - Ile 308
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.2 kDa. the protein migrates as 16-17 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).
Predicted Molecular Weight:
14.2 kDa
Purity:
>90% as determined by reduced SDS-PAGE.
physical-state:
Lyophilized
Buffer:
60% ACN, 0.085% TFA
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
GDF15
Additional Names:
GDF15,GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,NRG-1
Protein Accession Number:
NP_004855.2
Ncbi Gene Id Number:
9518
Background:
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
Background Reference 1:
Bootcov MR., et al. 1997, Proc Natl Acad Sci U S A., 94(21), 11514-9.
Background Reference 2:
Adela R., et al. 2015, J Diabetes Res., 2015, 490842.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-261

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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