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Cynomolgus DNAM-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Cynomolgus DNAM-1, His Tag at 2 ug/mL (100 uL/well) can bind Human CD155, Mouse IgG2a Fc Tag, low endotoxin with a linear range of 2-40 ng/mL (QC tested).
Immobilized Cynomolgus DNAM-1, His Tag at 2 ug/mL (100 uL/well) can bind Human Nectin-2, Fc Tag with a linear range of 5-40 ng/mL (Routinely tested).
Cynomolgus DNAM-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

DNAM-1 / CD226 Recombinant Protein

CATALOG NUMBER: 11-431

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Cynomolgus monkey
source-species:
HEK293 cells
Recombinant Protein Sequence:
Glu 19 - Phe 252
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
28.5 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
CD226
Additional Names:
DNAM1,CD226,PTA1
Protein Accession Number:
XP_005586537.1
Ncbi Gene Id Number:
102117316
Background:
DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Background Reference 1:
Shibuya A., et al.,1995, Immunity 4:573-581.
Background Reference 2:
Tahara-Hanaoka S., et al .,2003, Int. Immunol. 16:533-538.
Background Reference 3:
Pende D., et al.,2004, Mol. Immunol. 42:463-469.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-431

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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