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Frizzled-5 Recombinant Protein

CATALOG NUMBER: 90-313

Specifications
source-species:
HEK293 cells
Species:
Human, Mouse
source-species:
HEK293 cells
Recombinant Protein Sequence:
The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.
Fusion Tag:
Fc Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
Inhibits Wnt3a activation in a stoechiometric manner.
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
physical-state:
Lyophilized
Buffer:
Contains PBS. Reconstitute with 50 μl sterile water.
Concentration:
1mg/ml after reconstitution.
Storage Conditions:
Stable for at least 6 months after receipt when stored at -20°C.
Ncbi Official Symbol:
FZD5
Additional Names:
FzE5, Fz-5, hFz5
Protein Accession Number:
Q13467
Protein Gi Number:
27894385
Ncbi Gene Id Number:
7855
Background:
Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-313

List Size:
50 ug

List Price:

$473.00

Datasheet
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