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Beta-NGF Recombinant Protein

CATALOG NUMBER: 40-572

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/mL, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
physical-state:
Lyophilized
Storage Conditions:
The lyophilized Beta-NGF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Beta-NGF stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Beta-NGF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
NGF
Additional Names:
NGFB, HSAN5, Beta-NGF, NGFB, Beta-nerve growth factor
Protein Accession Number:
NP_002497.2
Protein Gi Number:
70995319
Ncbi Gene Id Number:
4803
Background:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-572

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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