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SDS-PAGE analysis of recombinant NELL2 fragment on Coomassie Blue-stained 12% SDS-PAGE gel.
SDS-PAGE analysis of recombinant NELL2 fragment on Coomassie Blue-stained 12% SDS-PAGE gel.

NELL2 Recombinant Protein

CATALOG NUMBER: 95-113

Tested Applications:
ELISA, WB
Specifications
source-species:
E. coli
Species:
Mouse
source-species:
E. coli
Recombinant Protein Sequence:
aa 22 - 238
Fusion Tag:
Fusion Partner: C-terminal His-tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for WB and ELISA. For research use only.
Predicted Molecular Weight:
28 kDa (Calculated)
Purity:
~95%
physical-state:
Liquid
Buffer:
100mM sodium phosphate, 10mM Tris, 500mM NaCl, 25 mM imidazole, 2mM MgCl2, 10% gycerol
Storage Conditions:
Store in working aliquots at -70°C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
Nell2
Additional Names:
NELL2 Recombinant Protein: mel91, R75516, A330108N19Rik
Protein Accession Number:
Q61220
Protein Gi Number:
2494290
Ncbi Gene Id Number:
54003
Background:
NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains (1). It is highly expressed in the hippocampus in vivo (2) and promotes survival of rat primary cultured neurons through activation of JNK and suppression of ERK (3). As ERK is required for the induction of hippocampal long term potentiation (LTP) and JNK appears to be inhibitory on LTP (4,5), it had been suggested that NELL2 may play a role in synaptic plasticity. More recently, NELL2 has been shown to promote differentiation of motor and sensory neurons and stimulates mitogenesis of dorsal root ganglia in chickens (6).
Background Reference 1:
Matsuhashi S, Noji S, Koyama E, et al. New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos. Dev. Dyn. 1995; 203:212-22.
Background Reference 2:
Oyasu M, Kuroda S, Nakashita M, et al. Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: light and electron microscopic studies in the rat brain. Mol. Brain Res. 2000; 76:151-60.
Background Reference 3:
Aihara K, Kuroda S, Kanamaya N, et al. A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases. Mol. Brain Res. 2003; 116:86-93.
Background Reference 4:
Rosenblum K, Futter M, Voss K, et al. The role of extracellular kinases I/II in late-phase long-term potentiation. J. Neurosci. 2002; 22:5432-41.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

95-113

List Size:
0.05 mg

List Price:

$289.00

Datasheet
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