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Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Bcl-xL Antibody

CATALOG NUMBER: 3341

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%), Rat: (100%), Mouse: (100%)
Immunogen:
Bcl-xL antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human Bcl-xL.
The immunogen is located within the last 50 amino acids of Bcl-xL.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Bcl-xL antibody can be used for detection of Bcl-xL by Western blot at 1 to 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1203 - A549 Cell Lysate
Purification:
Bcl-xL Antibody is supplied as ion exchange chromatography purified IgG.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Bcl-xL Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Bcl-xL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
BCL2L1
Additional Names:
Bcl-xL Antibody: BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S, BCLX, Bcl-2-like protein 1, Apoptosis regulator Bcl-X, Bcl2-L-1
Protein Accession Number:
CAA80661
Protein Gi Number:
510901
Ncbi Gene Id Number:
598
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.
Background Reference 1:
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Background Reference 2:
Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
Background Reference 3:
Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
Background Reference 4:
Gonzalez-Garcia M, Perez-Ballestro R, Ding L et al. bcl-xL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 1994; 120:3033-42.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3341

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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