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Western blot analysis of WNV Core in (A) untransfected or (B) transfected HeLa lysate with WNV Core antibody at 1 μg/mL.
Immunocytochemical staining of transfected Vero cells using WNV Core antibody at 20 μg/mL.
Western blot analysis of WNV Core in (A) untransfected or (B) transfected HeLa lysate with WNV Core antibody at 1 μg/mL.
Trial Size

West Nile Virus Core Antibody

CATALOG NUMBER: 3435

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, WB
Host Species:
Rabbit
Species Reactivity:
Virus
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Virus
Immunogen:
West Nile Virus Core antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy terminus of the West Nile Virus core protein.
The immunogen is located within amino acids 80 - 130 of West Nile Virus Core.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, WB
Application Note:
West Nile virus Core antibody can be used for the detection of the WNV Core protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL. This antibody will also detect the protein in immunoblot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in monkey samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 17-008 - THP-1 Cell Slide
Purification:
West Nile Virus Core Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
West Nile Virus Core Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
West Nile Virus Core antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
WNVgp1
Additional Names:
West Nile Virus Core Antibody: Genome polyprotein, Core protein, NS1
Protein Accession Number:
NP_776011
Protein Gi Number:
27735299
Ncbi Gene Id Number:
912267
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
West Nile Virus Core Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.
Background Reference 1:
Gould LH and Fikrig E. West Nile virus: a growing concern. J. Clin. Invest. 2004; 113:1102-7.
Background Reference 2:
Chu JJ, Rajamanonmani R, Li J, et al. Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein. J. Gen. Virol. 2005; 86:405-12.
Background Reference 3:
Chu JJ and Ng ML. Interaction of West Nile virus with α v β 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41.
Background Reference 4:
Yang JS, Ramanathan MP, Muthumani K, et al. Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway. Emerg. Infect. Dis. 2002; 8:1379-84.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3435

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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