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Western blot analysis of TRPC3 in human heart tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody at 10 μg/mL.
Western blot analysis of TRPC3 in human heart tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

TRPC3 Antibody

CATALOG NUMBER: 3895

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%)
Immunogen:
TRPC3 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TRPC3.
The immunogen is located within amino acids 120 - 170 of TRPC3.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
TRPC3 antibody can be used for the detection of TRPC3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Specificity:
This antibody may cross-react with TRPC6 and TRPC7.
Positive Control 1:
Cat. No. 1301 - Human Heart Tissue Lysate
Predicted Molecular Weight:
Predicted: 93 kDa
Observed: 100 kDa
Purification:
TRPC3 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TRPC3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TRPC3 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures..
Ncbi Official Symbol:
TRPC3
Additional Names:
TRPC3 Antibody: TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3
Protein Accession Number:
CAA74083
Protein Gi Number:
2225937
Ncbi Gene Id Number:
7222
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TRPC3 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
Background Reference 1:
Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.
Background Reference 2:
Trebak M, Vazquez G, Bird GSJ, et al. The TRPC3/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61.
Background Reference 3:
Zitt C, Obukhov AG, Strubing C, et al. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J. Cell. Biol. 1997; 1333-41.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3895

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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