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Western blot analysis of TRBP1 in 3T3 cell lysate with TRBP1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of TRBP1 in 3T3 cell lysate with TRBP1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

TRBP1 Antibody

CATALOG NUMBER: 4011

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
TRBP1 antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRBP1.
The immunogen is located within amino acids 1310 - 1360 of TRBP1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TRBP1 antibody can be used for detection of TRBP1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1212 - 3T3 Cell Lysate
Purification:
TRBP1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TRBP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TRBP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TARBP1
Additional Names:
TRBP1 Antibody: TRM3, TRP185, TRP-185, TRM3, Probable methyltransferase TARBP1, TAR RNA-binding protein 1
Protein Accession Number:
NP_005637
Protein Gi Number:
110825988
Ncbi Gene Id Number:
6894
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TRBP1 Antibody: The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1α (EF-1α), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB). TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.
Background Reference 1:
Gatignol A, Buckler-White A, Berkhout B, et al. Characterization of a human TAR REN-binding protein that activates the HIV-1 LTR. Science 1991; 251:1597-1600.
Background Reference 2:
Wu-Baer F, Lane WS, and Gaynor RB. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J. Biol. Chem.1996; 271:4201-8.
Background Reference 3:
Wu-Baer F, Lane WS, and Gaynor RB. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 1995; 14:5995-6009.

(07-01D)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4011

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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