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Western blot analysis of 125 ng of Transthyretin recombinant protein with Transthyretin antibody at 1 μg/mL.
Immunohistochemistry of Transthyretin in human lung tissue with Transthyretin antibody at 2.5 μg/mL.
Immunofluorescence of Transthyretin in human lung tissue with Transthyretin antibody at 20 μg/mL.
Western blot analysis of Transthyretin in HepG2 cell lysate with Transthyretin antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of 125 ng of Transthyretin recombinant protein with Transthyretin antibody at 1 μg/mL.
Trial Size

Transthyretin Antibody

CATALOG NUMBER: 5157

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Chicken
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Chicken
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (94%), Sheep: (88%), Rabbit: (82%), Pig: (82%)
Immunogen:
Transthyretin antibody was raised against a 17 amino acid synthetic peptide near the center of human Transthyretin.
The immunogen is located within amino acids 40 - 90 of Transthyretin.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Transthyretin antibody can be used for detection of Transthyretin by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1211 - HepG2 Cell Lysate
Positive Control 2:
Cat. No. 10-101 - Human Lung Tissue Slide
Predicted Molecular Weight:
Predicted: 15 kDa
Observed: 16 kDa
Purification:
Transthyretin Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgY
physical-state:
Liquid
Buffer:
Transthyretin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Transthyretin antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures
Ncbi Official Symbol:
TTR
Additional Names:
Transthyretin Antibody: CTS, CTS1, PALB, TBPA, HEL111, HsT2651, Transthyretin, ATTR
Protein Accession Number:
P02766
Protein Gi Number:
136464
Ncbi Gene Id Number:
7276
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Transthyretin Antibody: Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson's disease, schizophrenia, and depression.
Background Reference 1:
Fleming CE, Nunes AF, and Sousa MM. Transthyretin: more than meets the eye. Prog. Neurobiol.2009; 89:266-76.
Background Reference 2:
Fleming CE, Saraiva MJ, and Sousa MM. Transthyretin enhances nerve regeneration. J. Neurochem. 2007; 103:831-9.
Background Reference 3:
Rite I, Arguelles S, Venero JL, et al. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. J. Neurosci. Res. 2007; 85:3607-18.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5157

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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