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Western blot analysis of Prosapip1 in SK-N-SH cell lysate with Prosapip1 antibody at 1 μg/mL.
Immunohistochemistry of Prosapip1 in rat brain tissue with Prosapip1 antibody at 2.5 μg/mL.
Immunofluorescence of Prosapip 1 in rat brain tissue with Prosapip 1 antibody at 20 μg/mL.
Western blot analysis of Prosapip1 in SK-N-SH cell lysate with Prosapip1 antibody at 1 μg/mL.
Trial Size

Prosapip1 Antibody

CATALOG NUMBER: 5395

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Prosapip1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip1.
The immunogen is located within amino acids 590 - 640 of Prosapip1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Prosapip1 antibody can be used for detection of Prosapip1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1220 - SK-N-SH Cell Lysate
Purification:
Prosapip1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Prosapip1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Prosapip1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ProSAPiP1
Additional Names:
Prosapip1 Antibody: PROSAPIP1, KIAA0552, PROSAPIP1, Leucine zipper putative tumor suppressor 3, ProSAP-interacting protein 1, ProSAPiP1
Protein Accession Number:
NP_055546
Protein Gi Number:
7662176
Ncbi Gene Id Number:
9762
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Prosapip1 Antibody: Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3's PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.
Background Reference 1:
Wendholt D, Spilker C, Schmitt A, et al. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein proSAP2/Shank3. J. Biol. Chem.2006; 281:13805-16.
Background Reference 2:
Redecker P, Bockmann J, and Bockers TM. Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density. Cell Tissue Res.2007; 328:49-55.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5395

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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