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Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 μg/mL.
Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

TMEM38A Antibody

CATALOG NUMBER: 5521

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (94%), Bovine: (94%), Chicken: (76%)
Immunogen:
TMEM38A antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A.
The immunogen is located within the last 50 amino acids of TMEM38A.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
TMEM38A antibody can be used for detection of TMEM38A by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate
Purification:
TMEM38A Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TMEM38A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TMEM38A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TMEM38A
Additional Names:
TMEM38A Antibody: TRICA, TRIC-A, Trimeric intracellular cation channel type A, Transmembrane protein 38A
Protein Accession Number:
AAH01195
Protein Gi Number:
12654711
Ncbi Gene Id Number:
79041
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TMEM38A Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Background Reference 1:
Yazawa M, Ferrante C, Feng J, et al. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature2007; 448:78-82.
Background Reference 2:
Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther.2009; 121:265-72.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5521

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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