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Western blot analysis of STAU1 in rat brain tissue lysate with STAU1 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of STAU1 in human brain tissue with STAU1 antibody at 10 μg/mL.
Immunofluorescence of STAU1 in Human Brain cells with STAU1 antibody at 20 μg/mL.
Western blot analysis of STAU1 in rat brain tissue lysate with STAU1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

STAU1 Antibody

CATALOG NUMBER: 5997

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
STAU1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human STAU1.
The immunogen is located within the last 50 amino acids of STAU1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
STAU1 antibody can be used for detection of STAU1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1463 - Rat Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Purification:
STAU1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
STAU1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
STAU1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
STAU1
Additional Names:
STAU1 Antibody: STAU, STAU, Double-stranded RNA-binding protein Staufen homolog 1
Protein Accession Number:
NP_059347
Protein Gi Number:
82659087
Ncbi Gene Id Number:
6780
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
STAU1 Antibody: STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.
Background Reference 1:
Marion RM, Fortes P, Peloso A, et al. A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol. Cell. Biol.1999; 19:2212-9.
Background Reference 2:
de Lucas S, Peredo J, Marion RM, et al. Human Staufen1 protein interacts with influenza virus nucleoproteins and is required for efficient virus multiplication. J. Virol.2010; 84:7603-12.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5997

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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