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Western blot analysis of TMEM192 in SK-N-SH cell lysate with TMEM192 antibody at 0.5 μg/mL.
Immunohistochemistry of TMEM192 in mouse brain tissue with TMEM192 antibody at 5 μg/mL.
Immunofluorescence of TMEM192 in mouse brain tissue with TMEM192 antibody at 20 μg/mL.
Western blot analysis of TMEM192 in SK-N-SH cell lysate with TMEM192 antibody at 0.5 μg/mL.
Trial Size

TMEM192 Antibody

CATALOG NUMBER: 6227

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
TMEM192 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TMEM192.
The immunogen is located within amino acids 180 - 230 of TMEM192.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TMEM192 antibody can be used for detection of TMEM192 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
At least two isoforms of TMEM192 are known to exist; this antibody will recognize both. TMEM192 antibody is predicted to not cross-react with other TMEM proteins.
Positive Control 1:
Cat. No. 1220 - SK-N-SH Cell Lysate
Purification:
TMEM192 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TMEM192 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TMEM192 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TMEM192
Additional Names:
TMEM192 Antibody: Transmembrane protein 192
Protein Accession Number:
NP_001093859
Protein Gi Number:
154240704
Ncbi Gene Id Number:
201931
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TMEM192 Antibody: TMEM192 is a widely expressed, four transmembrane protein that localizes to late endosomal/lysosomal membranes. This localization is mediated by two dileucine motifs present at the amino-terminus of TMEM192. A cysteine residue near the carboxy residue is responsible for disulfide bond formation in TMEM192 homodimers. Little is known about the function of this protein.
Background Reference 1:
Schroder B, Wrocklage C, Hasilik A, et al. Molecular characterisation of ‘transmembrane protein 192'(TMEM192, a novel protein of the lysosomal membrane. Biol. Chem. 2010; 391:695-704.
Background Reference 2:
Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6227

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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