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Western blot analysis of ZIMP7 in A20 cell lysate with ZIMP7 antibody at (A) 0.25 μg/ml and (B) 0.5 μg/mL.
Western blot analysis of ZIMP7 in A20 cell lysate with ZIMP7 antibody at (A) 0.25 μg/ml and (B) 0.5 μg/mL.
Trial Size

ZIMP7 Antibody

CATALOG NUMBER: 6235

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
ZIMP7 antibody was raised against a 17 amino acid synthetic peptide near the center of human ZIMP7.
The immunogen is located within amino acids 270 - 320 of ZIMP7.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
ZIMP7 antibody can be used for detection of ZIMP7 by Western blot at 0.25 - 0.5 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Specificity:
At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.
Positive Control 1:
Cat. No. 1288 - A20 Cell Lysate
Purification:
ZIMP7 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
ZIMP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
ZIMP7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ZMIZ2
Additional Names:
ZIMP7 Antibody: NET27, ZIMP7, hZIMP7, TRAFIP20, KIAA1886, HRIHFB2007, Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7
Protein Accession Number:
Q8NF64
Protein Gi Number:
54607108
Ncbi Gene Id Number:
83637
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ZIMP7 Antibody: ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR)- mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.
Background Reference 1:
Huang CY, Beliakoff J, Li X, et al. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol. Endocrinol. 2005; 19:2915-29
Background Reference 2:
Ueki N, Oda T, Kondo M, et al. Selection system for genes encoding nuclear-targeted proteins. Nat. Biotechnol. 1998; 16:1338-42.
Background Reference 3:
Beliakoff J and Sun Z. Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl. Recept. Signal. 2006; 4:e017
Background Reference 4:
Peng Y, Lee J, Zhu C, et al. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J. Biol. Chem. 2010; 285:11465-75.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6235

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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