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Western blot analysis of Translin in rat lung tissue lysate with Translin antibody at (A) 0.5 and (B) 1 μg/mL
Immunohistochemistry of Translin in human lung tissue with Translin antibody at 5 μg/mL.
Immunofluorescence of Translin in human lung tissue with Translin antibody at 20 μg/mL.
Western blot analysis of Translin in rat lung tissue lysate with Translin antibody at (A) 0.5 and (B) 1 μg/mL
Trial Size

Translin Antibody

CATALOG NUMBER: 6369

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)
Immunogen:
Translin antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human Translin.
The immunogen is located within the last 50 amino acids of Translin.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Translin antibody can be used for detection of Translin by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
At least two isoforms of Translin are known to exist; this antibody will detect both.
Positive Control 1:
Cat. No. 1462 - Rat Lung Tissue Lysate
Positive Control 2:
Cat. No. 10-101 - Human Lung Tissue Slide
Purification:
Translin Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Translin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Translin antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TSN
Additional Names:
Translin Antibody: C3PO, RCHF1, TBRBP, TRSLN, BCLF-1, REHF-1, Translin, Component 3 of promoter of RISC, C3PO
Protein Accession Number:
NP_004613
Protein Gi Number:
4759270
Ncbi Gene Id Number:
7247
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Translin Antibody: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
Background Reference 1:
Aoki K, Susuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nat. Genet. 1995; 10:167-74.
Background Reference 2:
Li Z, Wu Y, and Baraban JM. The Translin/Trax RNA binding complex: clues to function in the nervous system. Biochim. Biophys. Acta 2008; 1779:479-85

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6369

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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