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Western blot analysis of TYW3 in A549 cell lysate with TYW3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Western blot analysis of TYW3 in A549 cell lysate with TYW3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

TYW3 Antibody

CATALOG NUMBER: 6377

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (94%)
Immunogen:
TYW3 antibody was raised against a 17 amino acid synthetic peptide near the center of human TYW3.
The immunogen is located within amino acids 160 - 210 of TYW3.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
TYW3 antibody can be used for detection of TYW3 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
TYW3 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW3 are known to exist; this antibody will detect both isoforms.
Positive Control 1:
Cat. No. 1203 - A549 Cell Lysate
Purification:
TYW3 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TYW3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TYW3
Additional Names:
TYW3 Antibody: C1orf171, C1orf171, tRNA wybutosine-synthesizing protein 3 homolog, tRNA-yW-synthesizing protein 3
Protein Accession Number:
Q6IPR3
Protein Gi Number:
42734381
Ncbi Gene Id Number:
127253
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TYW3 Antibody: TYW3 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.
Background Reference 1:
Noma A and Suzuki T. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Nucleic Acids Symp. Ser. (Oxf) 2006; 65-6.
Background Reference 2:
Noma A, Kirino Y, Ikeuchi Y, et al. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J. 2006; 25:2142-54

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6377

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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