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Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 μg/mL.
Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 μg/mL.
Immunofluorescence of TMEM59L in mouse brain tissue with TMEM59L antibody at 20 μg/mL.
Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 μg/mL.
Trial Size

TMEM59L Antibody

CATALOG NUMBER: 6435

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (89%)
Immunogen:
TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L.
The immunogen is located within amino acids 220 - 270 of TMEM59L.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
TMEM59L antibody can be used for detection of TMEM59L by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.
Positive Control 1:
Cat. No. 1461 - Rat Heart Tissue Lysate
Purification:
TMEM59L Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TMEM59L Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TMEM59L antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TMEM59L
Additional Names:
TMEM59L Antibody: BSMAP, C19orf4, BSMAP, Transmembrane protein 59-like, Brain-specific membrane-anchored protein
Protein Accession Number:
NP_036241
Protein Gi Number:
6912274
Ncbi Gene Id Number:
25789
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.
Background Reference 1:
Schöbel S, Neumann S, Seed B, et al. Expression cloning screen for modifiers of amyloid precursor protein shedding. Int. J. Dev. Neurosci. 2006; 24:141-8.
Background Reference 2:
Schöbel S, Neumann S, Hertweck M, et al. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 2008; 283:14257-68.
Background Reference 3:
Elson GC, de Coignac AB, Aubry JP, et al. BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. Biochem. Biophys. Res. Commun. 1999; 264:55-62.
Background Reference 4:
Ullrich S, Münch A, Neumann S, et al. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 2010; 285:20664-74.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6435

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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$65 Standard Overnight flat rate for as many products shipped within the United States.

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