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Western blot analysis of FXYD7 in human lung tissue lysate with FXYD7 antibody at 1 μg/mL.
Immunohistochemistry of FXYD7 in rat lung tissue with FXYD7 antibody at 2.5 μg/mL.
Immunofluorescence of FXYD4 in rat lung tissue with FXYD4 antibody at 20 μg/mL.
Western blot analysis of FXYD7 in human lung tissue lysate with FXYD7 antibody at 1 μg/mL.
Trial Size

FXYD7 Antibody

CATALOG NUMBER: 6465

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (71%)
Immunogen:
FXYD7 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human FXYD7.
The immunogen is located within the first 50 amino acids of FXYD7.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
FXYD7 antibody can be used for detection of FXYD7 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificity:
FXYD7 antibody is human, mouse and rat reactive. FXYDY7 antibody is predicted to not react with other members of the FXDY protein family
Positive Control 1:
Cat. No. 1302 - Human Lung Tissue Lysate
Purification:
FXYD7 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
FXYD7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
FXYD7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FXYD7
Additional Names:
FXYD7 Antibody: FXYD domain-containing ion transport regulator 7
Protein Accession Number:
AAH18619
Protein Gi Number:
11612659
Ncbi Gene Id Number:
53822
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.
Background Reference 1:
Beguin P, Crambert G, Monnet-Tschudi F, et al. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha1-beta isozymes. EMBO J. 2002; 21:3264-73
Background Reference 2:
Crambert G and Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Sci. STKE 2003; 2003 (166):RE1.
Background Reference 3:
Li C, Crambert G, Thuillard D, et al. role of the transmembrane domain of FXDY7 in structural and functional interactions with Na,K-ATPase. J. Biol. Chem. 2005; 280:42738-43.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6465

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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