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Western blot analysis of RASSF6 in 293 cell lysate with RASSF6 antibody at 1 μg/mL.
Western blot analysis of RASSF6 in 293 cell lysate with RASSF6 antibody at 1 μg/mL.
Trial Size

RASSF6 Antibody

CATALOG NUMBER: 6543

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (93%), Rat: (93%)
Immunogen:
RASSF6 antibody was raised against a 14 amino acid synthetic peptide near the center of human RASSF6.
The immunogen is located within amino acids 230 - 280 of RASSF6.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
RASSF6 antibody can be used for detection of RASSF6 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
At least four isoforms of RASSF6 are known to exist. RASSF6 antibody is predicted to not cross-react with other RASSF family members.
Positive Control 1:
Cat. No. 1210 - HEK293 Cell Lysate
Purification:
RASSF6 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
RASSF6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
RASSF6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RASSF6
Additional Names:
RASSF6 Antibody: Ras association domain-containing protein 6
Protein Accession Number:
NP_803876
Protein Gi Number:
41393610
Ncbi Gene Id Number:
166824
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
RASSF6 Antibody: RASSF family proteins are tumor suppressors that are frequently downregulated during the development of human cancer. RASSF6 (Ras association (RalGDS/AF-6) domain family member 6), a member of RASSF family, acts as a Ras effector protein / tumor suppressor. RASSF6 contains one Ras-associating domain and one SARAH domain. It is involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. Defects in RASSF6 may facilitate viral NFκ-B pathway and may play a vital role in infection.
Background Reference 1:
Van der Weyden L, Adams DJ. The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim. Biophys. Acta 2007; 1776:58-85
Background Reference 2:
Allen NP, Donninger H, Vos MD, et al. RASSF6 is a novel member of the RASSF family of tumor suppressors. Oncogene 2007; 26:6203-11
Background Reference 3:
Ikeda M, Hirabayashi S, Fujiwara N, et al. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp. Cell Res. 2007; 313:1484-95

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6543

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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