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Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 μg/mL.
Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 μg/mL.
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TAB2 Antibody

CATALOG NUMBER: 3389

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (86%), Mouse: (79%)
Immunogen:
TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2.
The immunogen is located within the last 50 amino acids of TAB2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P
Application Note:
TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity:
TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
Positive Control 1:
Cat. No. 10-301 - Human Brain Tissue Slide
Purification:
TAB2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
TAB2 Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TAB2 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TAB2
Additional Names:
TAB2 Antibody: CHTD2, MAP3K7IP2, KIAA0733, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2
Protein Accession Number:
NP_055908
Protein Gi Number:
14149669
Ncbi Gene Id Number:
23118
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Background Reference 1:
Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 2000; 5:649-58.
Background Reference 2:
Maizukami J, Takaesu G, Akatsuka H, et al. Receptor activation of NF-kappaB lingand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 2002; 22:992-1000.
Background Reference 3:
Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3389

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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