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Western blot analysis of TTYH1 in Raji cell lysate with TTYH1 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of TTYH1 in Raji cells with TTYH1 antibody at 5 μg/mL.
Western blot analysis of TTYH1 in Raji cell lysate with TTYH1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

TTYH1 Antibody

CATALOG NUMBER: 6883

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
TTYH1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TTYH1.
The immunogen is located within the last 50 amino acids of TTYH1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, WB
Application Note:
TTYH1 antibody can be used for detection of TTYH1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Specificity:
TTYH1 antibody is human specific. Multiple isoforms of TTYH1 are known to exist.
Positive Control 1:
Cat. No. 1207 - Raji Cell Lysate
Positive Control 2:
Cat. No. 17-007 - Raji Cell Slide
Purification:
TTYH1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
TTYH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
TTYH1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TTYH1
Additional Names:
TTYH1 Antibody: Protein tweety homolog 1, hTTY1
Protein Accession Number:
NP_001005367
Protein Gi Number:
53831989
Ncbi Gene Id Number:
57348
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
TTYH1 Antibody: TTYH1 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH1 is a Ca2+-independent, volume-sensitive large conductance chloride (Cl-) channel. TTYH1 is primarily expressed in neural tissue and upregulated in astrocytoma, glioma, and several other cancers. Recent experiments have shown that TTYH1 is an integral endoplasmic reticulum (ER) membrane protein involved in cell proliferation and is thought to play an essential role in embryonic cell growth, possibly through the Ca2+ storage/release process in ER membranes during early development.
Background Reference 1:
Campbell HD, Kamei M, Caludianos C, et al. Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. Genomics 2000; 68:89-92.
Background Reference 2:
Matthews CA, Shaw JE, Hooper JA, et al. Expression and evolution of the mammalian brain gene Ttyh1. J. Neurochem. 100:693-707
Background Reference 3:
Kumada T, Yamanaka Y, Kitano A, et al. Ttyh1, a Ca2+-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev. Dyn. 2010; 239:2233-45.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6883

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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