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Western blot analysis of MYCT1 in rat lung tissue lysate with MYCT1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of MYCT1 in rat lung tissue lysate with MYCT1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

MYCT1 Antibody

CATALOG NUMBER: 7031

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
MYCT1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human MYCT1.
The immunogen is located within the last 50 amino acids of MYCT1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
MYCT1 antibody can be used for detection of MYCT1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Specificity:
At least two isoforms of MYCT1 are known to exist; this antibody will detect both isoforms.
Positive Control 1:
Cat. No. 1462 - Rat Lung Tissue Lysate
Predicted Molecular Weight:
26 kDa
Purification:
MYCT1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
MYCT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
MYCT1 antibody can be stored at 4°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MYCT1
Additional Names:
MYCT1 Antibody: MTLC, MTLC, MTMC1, Myc target protein 1, Myc target in myeloid cells protein 1
Protein Accession Number:
NP_079383
Protein Gi Number:
156151389
Ncbi Gene Id Number:
80177
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MYCT1 Antibody: MYCT1 was initially identified as a novel target of the c-Myc oncogene in myeloid cells. It is a widely expressed nuclear protein whose overexpression can promote apoptosis, alteration of morphology, enhancement of anchorage-independent cell growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. MYCT1 binds to the promoters of several c-Myc-regulated genes and it has been suggested that the phenotypes seen in MYCT1-overexpressing cells are a result of the deregulation of these genes. RUNX1-ETO, a fusion protein made up of RUNX1 and ETO, is thought to deregulate the proliferation and responsiveness of human hematopoietic progenitor cells downstream of MYCT1.
Background Reference 1:
Yin X, Grove L, Rogulski K, et al. Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes. J. Biol. Chem. 2002; 277:19998-20010.
Background Reference 2:
Rogulski KR, Cohen DE, Corcoran DL, et al. Deregulation of common genes by c-Myc and its direct target, MT-MC1. Proc. Natl. Acad. Sci. USA 2005; 102:18968-73.
Background Reference 3:
Liddiard K, Burnett AK, Darley RL, et al. RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1. Leukemia 2012; 26:177-9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7031

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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