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Western blot analysis of MYT1L in mouse brain tissue lysate with MYT1L antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of MYT1L in human brain with MYT1L antibody at 20 μg/mL.
Western blot analysis of MYT1L in mouse brain tissue lysate with MYT1L antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

MYT1L Antibody

CATALOG NUMBER: 7083

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L.
The immunogen is located within the last 50 amino acids of MYT1L.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
MYT1L antibody can be used for detection of MYT1L by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
At least three isoforms are known to exist. This antibody will only recognize the two longest isoforms.
Positive Control 1:
Cat. No. 1403 - Mouse Brain Tissue Lysate
Predicted Molecular Weight:
130 kDa
Purification:
MYT1L Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
MYT1L Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
MYT1L antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MYT1L
Additional Names:
MYT1L Antibody: NZF1, ZC2HC4B, KIAA1106, Myelin transcription factor 1-like protein, MyT1-L
Protein Accession Number:
NP_055840
Protein Gi Number:
60498973
Ncbi Gene Id Number:
23040
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MYT1L Antibody: The myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.
Background Reference 1:
Romm E, Nielsen JA, Kim JG, et al. Myt1 family recruits histone deacetylase to regulate neural transcription. J. Neurochem. 2005; 93:1444-53
Background Reference 2:
Li W, Wang X, Zhao J, et al. Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav. 2012; 11:87-93.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7083

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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$35 Dry Ice Shipment fee may be required on some items.

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