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Western blot analysis of PIBF1 in human placenta tissue lysate with PIBF1 antibody at (A) 1 and (B) 2 μg/mL
Immunohistochemistry of PBIF in human spleen tissue with PBIF antibody at 5 μg/ml.
Immunofluorescence of PBIF in human spleen tissue with PBIF antibody at 20 μg/ml.
Western blot analysis of PIBF1 in human placenta tissue lysate with PIBF1 antibody at (A) 1 and (B) 2 μg/mL
Trial Size

PIBF1 Antibody

CATALOG NUMBER: 7237

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Rabbit polyclonal PIBF1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PIBF1.
The immunogen is located within amino acids 610 - 660 of PIBF1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
PIBF1 antibody can be used for detection of PIBF1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
Multiple isoforms of PIBF1 exists as a result of alternative splicing event.
Positive Control 1:
Cat. No. 1309 - Human Placenta Tissue Lysate
Positive Control 2:
Cat. No. 10-901 - Human Spleen Tissue Slide
Predicted Molecular Weight:
83 kDa
Purification:
PIBF1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PIBF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PIBF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
PIBF1
Additional Names:
PIBF1 Antibody: PIBF, CEP90, C13orf24, PIBF, Progesterone-induced-blocking factor 1
Protein Accession Number:
NP_006337
Protein Gi Number:
5576958
Ncbi Gene Id Number:
10464
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.
Background Reference 1:
Laskarin G, Tokmadzic VS, Strbo N, et al. Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am. J. Reprod. Immunol. 2002; 48:201-9.
Background Reference 2:
Lachmann M, Gelbmann D, Kalman E, et al. PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. Int. J. Cancer. 2004; 112:51-60
Background Reference 3:
Polgar B, Kispal G, Lachmann M, et al. Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. J. Immunol. 2003; 171:5956-63.
Background Reference 4:
Raghupathy R, Al-Mutawa E, Al-Azemi M, et al. Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. J. Reprod. Immunol. 2009; 80:91-9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7237

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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$65 Standard Overnight flat rate for as many products shipped within the United States.

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