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Immunohistochemistry of RIM2 in human adrenal gland tissue with RIM2 antibody at 5 μg/mL.
Immunohistochemistry of RIM2 in human adrenal gland tissue with RIM2 antibody at 5 μg/mL.
Trial Size

RIM2 Antibody

CATALOG NUMBER: 4445

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)
Immunogen:
RIM2 antibody was raised against a 16 amino acid peptide near the carboxy terminusof human RIM2.
The immunogen is located within amino acids 30 - 80 of RIM2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P
Application Note:
RIM2 antibody can be used for detection of RIM2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Predicted Molecular Weight:
Predicted: 148 kDa
Purification:
RIM2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
RIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
RIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
RIMS2
Additional Names:
RIM2 Antibody: OBOE, RIM2, RAB3IP3, KIAA0751, Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2
Protein Accession Number:
NP_001093587
Protein Gi Number:
154354983
Ncbi Gene Id Number:
9699
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM1 and RIM2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM1, RIM2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
Background Reference 1:
Wang Y, Sugita S, and Sudhof TC. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem. 2000; 275:20033-44.
Background Reference 2:
Liang F, Zhang B, Tang J, et al. RIM3gamma is a postsynaptic protein in the rat central nervous system. J. Comp. Neurol. 2007; 503:501-10
Background Reference 3:
Shoch S, Mittelstaedt T, Kaeser PS, et al. Redundant functions of RIM1α and RIM2α in Ca2+-triggered neurotransmitter release. EMBO J. 2006; 25:5852-63.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4445

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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