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Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 μg/ml.
Immunohistochemistry of XKR8 in human stomach tissue with XKR8 antibody at 5 μg/ml.
Immunofluorescence of XKR8 in human stomach tissue with XKR8 antibody at 20 μg/ml.
Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 μg/ml.
Trial Size

XKR8 Antibody

CATALOG NUMBER: 7965

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8.
The immunogen is located within the last 50 amino acids of XKR8.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Positive Control 1:
Cat. No. 1319 - Human Stomach Tissue Lysate
Positive Control 2:
Cat. No. 10-801 - Human Stomach Tissue Slide
Predicted Molecular Weight:
Predicted: 43 kDa
Observed: 47 kDa
Purification:
XKR8 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
XKR8 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
XKR8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
XKR8
Additional Names:
XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8
Protein Accession Number:
NP_060523
Protein Gi Number:
24431977
Ncbi Gene Id Number:
55113
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).
Background Reference 1:
Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6.
Background Reference 2:
Wang X, Wu YC, Fadok VA, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302:1563-6.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7965

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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