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Western blot analysis of SLCO1B1 in human liver tissue lysate with SLCO1B1 antibody at 1 μg/ml.
Immunocytochemistry of SLCO1B1 in HepG2 cells with SLCO1B1 antibody at 2.5 μg/ml.
Immunofluorescence of SLCO1B1 in human liver tissue with SLCO1B1 antibody at 20 μg/ml.
Western blot analysis of SLCO1B1 in human liver tissue lysate with SLCO1B1 antibody at 1 μg/ml.
Trial Size

SLCO1B1 Antibody

CATALOG NUMBER: 8197

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
SLCO1B1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLCO1B1.
The immunogen is located within the last 50 amino acids of SLCO1B1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, WB
Application Note:
SLCO1B1 antibody can be used for detection of SLCO1B1 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins.
Positive Control 1:
Cat. No. 1304 - Human Liver Tissue Lysate
Positive Control 2:
Cat. No. 10-201 - Human Liver Tissue Slide
Predicted Molecular Weight:
Predicted: 76 kDa
Observed: 75 kDa
Purification:
SLCO1B1 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SLCO1B1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SLCO1B1 antibody can be stored at 4°C, stable for up to one year.
Ncbi Official Symbol:
SLCO1B1
Additional Names:
Solute carrier organic anion transporter family member 1B1, LST1, Solute carrier family 21 member 6, SLC21A6, Sodium-independent organic anion-transporting polypeptide 2, OATP1B1, OATP2, OATPC, Solute carrier family 21 member 6
Protein Accession Number:
NP_006437
Protein Gi Number:
225543525
Ncbi Gene Id Number:
10599
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2). It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3). SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4).
Background Reference 1:
Abe T, Kakyo M, Tokui T, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 1999; 274:17159-63.
Background Reference 2:
Konig J, Cui Y, Nies AT, et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 278:G156-64.
Background Reference 3:
Michalski C, Cui Y, Nies AT, et al. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J. Biol. Chem. 2002; 277:43058-63.
Background Reference 4:
Yao J, Hong W, Huang J, et al. N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLoS One 2012; 7:e52563.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8197

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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