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Western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the detected the C2 protein (arrow).
Western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the detected the C2 protein (arrow).

C2 Antibody

CATALOG NUMBER: 55-321

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Hamster, Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Hamster, Human
Immunogen:
This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
83 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
C2
Additional Names:
Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment, C2
Protein Accession Number:
P06681
Protein Gi Number:
3915642
Ncbi Gene Id Number:
717
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms.Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.
Background Reference 1:
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010)
Background Reference 4:
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-321

List Size:
400 ul

List Price:

$495.00

Datasheet
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