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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

SPG20 Antibody

CATALOG NUMBER: 58-376

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SPG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-519 amino acids from the C-terminal region of human SPG20.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
73 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SPG20
Additional Names:
Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1
Protein Accession Number:
Q8N0X7
Protein Gi Number:
50401600
Ncbi Gene Id Number:
23111
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SPG20 is a protein containing a MIT (MicrotubuleInteracting and Trafficking molecule) domain, and is implicated inregulating endosomal trafficking and mitochondria function. Theprotein localizes to mitochondria and partially co-localizes withmicrotubules. Stimulation with epidermal growth factor (EGF)results in protein translocation to the plasma membrane, and theprotein functions in the degradation and intracellular traffickingof EGF receptor. Multiple alternatively spliced variants, encodingthe same protein, have been identified. Mutations associated withthis gene cause autosomal recessive spastic paraplegia 20 (Troyersyndrome).
Background Reference 1:
Hooper, C., et al. BMC Biol. 8, 72 (2010) :
Background Reference 2:
Milewska, M., et al. J. Neurochem. 111(4):1022-1030(2009)
Background Reference 3:
Tsang, H.T., et al. Hum. Mol. Genet. 18(20):3805-3821(2009)
Background Reference 4:
Edwards, T.L., et al. Biochem. J. 423(1):31-39(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-376

List Size:
400 ul

List Price:

$495.00

Datasheet
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