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Western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the detected the Mouse Rnasel protein (arrow).
Western blot analysis in mouse spleen tissue lysates (35ug/lane).
Western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the detected the Mouse Rnasel protein (arrow).

Mouse Rnasel Antibody

CATALOG NUMBER: 59-203

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Immunogen:
This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
83 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
Rnasel
Additional Names:
2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, Rnasel, Rns4
Protein Accession Number:
Q05921
Ncbi Gene Id Number:
24014
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).
Background Reference 1:
Ireland, D.D., et al. PLoS Pathog.(10), E1000602 (2009) :
Background Reference 2:
Andersen, J.B., et al. RNA Biol 6(3):305-315(2009)
Background Reference 3:
Salehzada, T., et al. PLoS ONE(10), E7563 (2009) :
Background Reference 4:
Li, X.L., et al. Proc. Natl. Acad. Sci. U.S.A. 105(52):20816-20821(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-203

List Size:
400 ul

List Price:

$495.00

Datasheet
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