DMTF1 Antibody

Background:

This gene encodes a transcription factor that contains acyclin D-binding domain, three central Myb-like repeats, and twoflanking acidic transactivation domains at the N- and C-termini.The encoded protein is induced by the oncogenic Ras signalingpathway and functions as a tumor suppressor by activating thetranscription of ARF and thus the ARF-p53 pathway to arrest cellgrowth or induce apoptosis. It also activates the transcription ofaminopeptidase N and may play a role in hematopoietic celldifferentiation. The transcriptional activity of this protein isregulated by binding of D-cyclins. This gene is hemizygouslydeleted in approximately 40% of human non-small-cell lung cancerand is a potential prognostic and gene-therapy target fornon-small-cell lung cancer. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].