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Western blot analysis in HepG2 cell line lysates (35ug/lane).
Western blot analysis in HepG2 cell line lysates (35ug/lane).

MRGBP Antibody

CATALOG NUMBER: 59-644

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This MRGBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human MRGBP.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
22 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MRGBP
Additional Names:
MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, MRGBP, C20orf20
Protein Accession Number:
Q9NV56
Protein Gi Number:
28201787
Ncbi Gene Id Number:
55257
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Background Reference 1:
Yamaguchi, K., et al. Br. J. Cancer 102(2):325-331(2010)
Background Reference 2:
Cai, Y., et al. J. Biol. Chem. 280(14):13665-13670(2005)
Background Reference 3:
Cai, Y., et al. J. Biol. Chem. 278(44):42733-42736(2003)
Background Reference 4:
Deloukas, P., et al. Nature 414(6866):865-871(2001)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-644

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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