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Western blot analysis in mouse brain tissue lysates (35ug/lane).
Western blot analysis in mouse brain tissue lysates (35ug/lane).

PPP4R2 Antibody

CATALOG NUMBER: 59-916

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This PPP4R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-254 amino acids from the Central region of human PPP4R2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
47 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PPP4R2
Additional Names:
Serine/threonine-protein phosphatase 4 regulatory subunit 2, PPP4R2
Protein Accession Number:
Q9NY27
Protein Gi Number:
158564082
Ncbi Gene Id Number:
151987
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Background Reference 1:
Lee, D.H., et al. Nat. Struct. Mol. Biol. 17(3):365-372(2010)
Background Reference 2:
Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)
Background Reference 3:
Chowdhury, D., et al. Mol. Cell 31(1):33-46(2008)
Background Reference 4:
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-916

List Size:
400 ul

List Price:

$495.00

Datasheet
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