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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).

AKAP5 Antibody

CATALOG NUMBER: 60-359

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This AKAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human AKAP5.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
47 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
AKAP5
Additional Names:
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
Protein Accession Number:
P24588
Protein Gi Number:
281185503
Ncbi Gene Id Number:
9495
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The A-kinase anchor proteins (AKAPs) are a group ofstructurally diverse proteins, which have the common function ofbinding to the regulatory subunit of protein kinase A (PKA) andconfining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded proteinbinds to the RII-beta regulatory subunit of PKA, and also toprotein kinase C and the phosphatase calcineurin. It ispredominantly expressed in cerebral cortex and may anchor the PKAprotein at postsynaptic densities (PSD) and be involved in theregulation of postsynaptic events. It is also expressed in Tlymphocytes and may function to inhibit interleukin-2 transcriptionby disrupting calcineurin-dependent dephosphorylation of NFAT.
Background Reference 1:
Willoughby, D., et al. J. Biol. Chem. 285(26):20328-20342(2010)
Background Reference 2:
Chen, M.H., et al. Cell. Signal. 21(1):136-142(2009)
Background Reference 3:
Tavalin, S.J. J. Biol. Chem. 283(17):11445-11452(2008)
Background Reference 4:
Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-359

List Size:
400 ul

List Price:

$495.00

Datasheet
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