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PARP1 Antibody pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. PARP1 Antibody (arrow) was detected using the purified Pab.
PARP1 Antibody pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. PARP1 Antibody (arrow) was detected using the purified Pab.

PARP1 Antibody

CATALOG NUMBER: 60-736

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This PARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the N-terminal region of human PARP1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
113 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PARP1
Additional Names:
Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
Protein Accession Number:
P09874
Protein Gi Number:
130781
Ncbi Gene Id Number:
142
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a chromatin-associated enzyme,poly(ADP-ribosyl)transferase, which modifies various nuclearproteins by poly(ADP-ribosyl)ation. The modification is dependenton DNA and is involved in the regulation of various importantcellular processes such as differentiation, proliferation, andtumor transformation and also in the regulation of the molecularevents involved in the recovery of cell from DNA damage. Inaddition, this enzyme may be the site of mutation in Fanconianemia, and may participate in the pathophysiology of type Idiabetes.
Background Reference 1:
Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)
Background Reference 2:
Kim, M., et al. Cancer Sci. 101(11):2436-2442(2010)
Background Reference 3:
Dong, Y., et al. Cancer Res. 70(20):8088-8096(2010)
Background Reference 4:
Krishnakumar, R., et al. Mol. Cell 39(5):736-749(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-736

List Size:
400 ul

List Price:

$495.00

Datasheet
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