ADRA1B Antibody

CATALOG NUMBER: 60-786

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human ADRA1B.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
57 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ADRA1B
Additional Names:
Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B
Protein Accession Number:
P35368
Protein Gi Number:
116241241
Ncbi Gene Id Number:
147
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members ofthe G protein-coupled receptor superfamily. They activate mitogenicresponses and regulate growth and proliferation of many cells.There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all ofwhich signal through the Gq/11 family of G-proteins and differentsubtypes show different patterns of activation. This gene encodesalpha-1B-adrenergic receptor, which induces neoplastictransformation when transfected into NIH 3T3 fibroblasts and othercell lines. Thus, this normal cellular gene is identified as aprotooncogene. This gene comprises 2 exons and a single largeintron of at least 20 kb that interrupts the coding region.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Background Reference 3:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 4:
Jensen, B.C., et al. Circ Heart Fail 2(6):654-663(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-786

List Size:
400 ul

List Price:

$495.00

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