FMO5 Antibody

CATALOG NUMBER: 60-965

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This FMO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from the C-terminal region of human FMO5.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
60 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FMO5
Additional Names:
Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, Hepatic flavin-containing monooxygenase 5, FMO 5, FMO5
Protein Accession Number:
P49326
Protein Gi Number:
1346021
Ncbi Gene Id Number:
2330
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Metabolic N-oxidation of the diet-derivedamino-trimethylamine (TMA) is mediated by flavin-containingmonooxygenase and is subject to an inherited FMO3 polymorphism inman resulting in a small subpopulation with reduced TMA N-oxidationcapacity resulting in fish odor syndrome Trimethylaminuria. Threeforms of the enzyme, FMO1 found in fetal liver, FMO2 found in adultliver, and FMO3 are encoded by genes clustered in the 1q23-q25region. Flavin-containing monooxygenases are NADPH-dependentflavoenzymes that catalyzes the oxidation of soft nucleophilicheteroatom centers in drugs, pesticides, and xenobiotics.Alternative splicing results in multiple transcript variants.
Background Reference 1:
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Background Reference 2:
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
Background Reference 3:
Wheeler, H.E., et al. PLoS Genet.(10), E1000685 (2009) :
Background Reference 4:
Zhang, J., et al. Drug Metab. Dispos. 34(1):19-26(2006)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-965

List Size:
400 ul

List Price:

$495.00

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