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Western Blot at 1:2000 dilution Lane 1: human kidney lysate Lane 2: human liver lysate Lane 3: U-2OS whole cell lysate Lane 4: A431 whole cell lysate Lane 5: mouse kidney lysate Lysates/proteins at 20 ug per lane.
Western Blot at 1:2000 dilution Lane 1: human kidney lysate Lane 2: human liver lysate Lane 3: U-2OS whole cell lysate Lane 4: A431 whole cell lysate Lane 5: mouse kidney lysate Lysates/proteins at 20 ug per lane.

ACO1 Antibody

CATALOG NUMBER: 61-255

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Chicken
Immunogen:
This ACO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 354-388 amino acids from the Central region of human ACO1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:2000
Predicted Molecular Weight:
98 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ACO1
Additional Names:
Cytoplasmic aconitate hydratase, Aconitase, 4.2.1.3, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1
Protein Accession Number:
P21399
Protein Gi Number:
3123225
Ncbi Gene Id Number:
48
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Background Reference 1:
Hirling H.,et al.Nucleic Acids Res. 20:33-39(1992).
Background Reference 2:
Humphray S.J.,et al.Nature 429:369-374(2004).
Background Reference 3:
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Background Reference 4:
Rouault T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7958-7962(1990).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

61-255

List Size:
200 ul

List Price:

$495.00

Datasheet
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