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Western Blot at 1:1000 dilution Lane 1: human brain lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis of hITPKA-E360 in K562 cell line and mouse lung tissue lysates (35ug/lane)
Western Blot at 1:1000 dilution Lane 1: human brain lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 ug per lane.

ITPKA Antibody

CATALOG NUMBER: 63-441

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This ITPKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human ITPKA.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
51 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ITPKA
Additional Names:
Inositol-trisphosphate 3-kinase A, Inositol 1,5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A, ITPKA
Protein Accession Number:
P23677
Protein Gi Number:
124807
Ncbi Gene Id Number:
3706
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.
Background Reference 1:
Gonzalez, B., et al., Mol. Cell 15(5):689-701 (2004).
Background Reference 2:
Mishra, J., et al., Biophys. J. 83(3):1298-1316 (2002).
Background Reference 3:
Schell, M.J., et al., J. Biol. Chem. 276(40):37537-37546 (2001).
Background Reference 4:
Communi, D., et al., EMBO J. 16(8):1943-1952 (1997).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

63-441

List Size:
400 ul

List Price:

$495.00

Datasheet
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