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NS5B Antibody [5B-12B7]

CATALOG NUMBER: 36-097

Clonality:
Monoclonal
Tested Applications:
Functional Assays, ICC, IP
Host Species:
Mouse
Species Reactivity:
HCV
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
HCV
Immunogen:
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Conjugate:
Unconjugated
Tested Applications:
Functional Assays, ICC, IP
Application Note:
Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
Specificity:
Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.
Purification:
>95% (SDS-PAGE)
Clonality:
Monoclonal
Isotype:
IgG2a
physical-state:
Liquid
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C.
Additional Names:
Nonstructural Protein 5B
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-097

List Size:
100 ug

List Price:

$515.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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