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Caspase-11 Antibody [4E11]

CATALOG NUMBER: 36-183

Clonality:
Monoclonal
Tested Applications:
ELISA, Flow, IP, WB
Host Species:
Rat
Species Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse, Rat
Immunogen:
Recombinant mouse caspase-11 (p20 fragment).
Conjugate:
Unconjugated
Tested Applications:
ELISA, Flow, IP, WB
Application Note:
ELISA: (recombinant protein). Flow Cytometry: (overexpressed in cell lines). Immunoprecipitation: (1-5ug/ml). Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
Specificity:
Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.
Purification:
>95% (SDS-PAGE)
Clonality:
Monoclonal
Isotype:
IgG1, kappa
physical-state:
Liquid
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C.
Ncbi Official Symbol:
Casp4
Additional Names:
Caspase-11 (mouse); Protease ICH-3 (mouse)
Protein Accession Number:
341940314
Protein Gi Number:
P70343
Ncbi Gene Id Number:
12363
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-183

List Size:
100 ug

List Price:

$498.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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