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Recombinant

Olaratumab (PDGFRA/PDGFR2/CD140a) – Research Grade Biosimilar

CATALOG NUMBER: 10-439

Clonality:
Recombinant Monoclonal
Conjugate:
Unconjugated
Specifications
source-species:
CHO cells
source-species:
CHO cells
Immunogen:
Homo sapiens / PDGFRA/PDGFR2/CD140a [Homo sapiens]
Conjugate:
Unconjugated
Purification:
>95%
Clonality:
Recombinant Monoclonal
Isotype:
IgG1-kappa
Buffer:
PBS buffer pH7.5
Concentration:
batch dependent
Storage Conditions:
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for 1-2 weeks. Store at -20 °C for 12 months. Store at -80 °C for long term storage.
Additional Names:
3G3,IMC-3G3,LY3012207
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Studies show that the treatment of olaratumab in combination with doxorubicin resulted in significant reduction of cancer cell proliferation and tumor growth. Olaratumab was granted accelerated approval (as Lartruvo) as initial therapy to treat adults with certain types of soft tissue sarcoma (STS) in October, 2016.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

10-439

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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