CD20 Antibody [AISB12]

CATALOG NUMBER: 76-011

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The AISB12 monoclonal antibody specifically reacts with mouse cd20, a 32kDA B-lymphocyte surface molecule.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Rat IgG2a
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Ms4a1
Additional Names:
Cd20, Ly-44, Ms4a2, AA960661, Ms4a1
Ncbi Gene Id Number:
12482
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The AISB12 monoclonal antibody specifically reacts with mouse cd20, a 32kDA B-lymphocyte surface molecule. CD20 is expressed by B cells in all stage of development, except for the initial pro-B and final plasma cells. CD20 has no natural ligands and has an important role in enabling B cells to respond optimally to T-independent antigens. The AISB12 antibody binds to the extracellular loop domain of the CD20 molecule.
Background Reference 1:
Uchida, J., Hamaguchi, Y., Oliver, J. A., Ravetch, J. V., Poe, J. C., Haas, K. M., Tedder, T. F. (2004). The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptordependent mechanisms during anti-CD20 antibody immunotherapy.The Journal of experimental medicine,199(12), 1659-1669.
Background Reference 2:
Uchida, J., Lee, Y., Hasegawa, M., Liang, Y., Bradney, A., Oliver, J. A., ... Tedder, T. F. (2004). Mouse CD20 expression and function.International immunology,16(1), 119-129.
Background Reference 3:
Qian, J., Zheng, Y., Zheng, C., Wang, L., Qin, H., Hong, S., ... Yi, Q. (2012). Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma.Blood,119(1), 161-169.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-011

List Size:
0.5 mg

List Price:

$709.00

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